![]() ![]() Transfer (PT) reaction that itself leads to a highly reactive zwitterionic Widely accepted that the imidazole of His41 is the base of the proton Hydrolysis is mediated by the catalytic Cys145 via a nucleophilicĪttack on the carbonyl carbon of a susceptible peptide bond. Similar to other cysteine proteases, SARS-CoV-2 M pro features a cysteine-histidine catalytic dyad (Cys145/His41) Which is active in its dimeric form 2 (structuralĭetails are given in the Supporting Information, SI). SARS-CoV-2 M pro is a three-domain cysteine protease Might be obtained by targeting this enzyme. The coronavirus family, suggesting that broad-spectrum antiviral drugs Of M pro and its catalytic pocket is very similar among Human proteases, and thus inhibitors of its activity are less likely Of SARS-CoV-2 M pro is different from that of all known 1 Inhibition of its cleavage activity would therefore block The virus non-structural polyprotein at 11 sites. Plays a key role in viral replication and transcription, cleaving ![]() Is the main protease (M pro or 3CLpro), as this protein One of the most promising targets for drug development among coronaviruses The pandemic caused by severe acute respiratory syndrome coronavirusĢ (SARS-CoV-2) has led to an urgent need for effective therapeutics. ![]()
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